Section

Ecology

Title

THE ASSESSMENT OF THE SEVERITY OF OXIDATIVE STRESS IN THE ANIMALS IN THE EXPERIMENT UNDER THE INFLUENCE OF TOXICANTS OF ORGANIC AND INORGANIC ORIGIN

Сontributors

L. A. Chesnokova, PhD (Biology), Assistant Professor, This email address is being protected from spambots. You need JavaScript enabled to view it.;

S.I. Krasikov, PhD (Medicine), Dr. Habil., Professor, Head of Department, This email address is being protected from spambots. You need JavaScript enabled to view it.,

D.S. Karmanova, Senior Lecturer, This email address is being protected from spambots. You need JavaScript enabled to view it.

State budgetary educational institution of higher professional education "Orenburg state medical University" of the Ministry of health of Russia

Abstract

The influence of the low-dosed impact of cat¬ions of iron and herbicide 2,4-D on expressiveness of an oxidizing stress in rats was studied. The results of the research showed moderate activation of the processes of freely radical oxidation (FRO) when the studied substances were introduced separately and the most expressed effect of accumulation of the products of FRO — DC, HMM and decrease in activity of the SOD antioxidant enzymes and a ca¬talysis when they were applied jointly. 2,4-D active forms, which were formed as a result of a metabo¬lism of oxygen and the free radicals generated as a result of pro-oxidatic effect of iron, did not influ¬ence the development of an oxidizing stress at the isolated introduction, at joint action it led to consid¬erable accumulation of the products of FRO and de¬crease in activity of antioxidant enzymes.

Keywords

herbicide 2,4-D iron cations, com¬bined influence, rats, oxidizing stress.

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